Prostate Health & Disease The prostate gland has an important job: it produces a thick, milky-white fluid that becomes part of the semen, the liquid ejaculated during sexual activity. The gland isn't big—about the size of a walnut or golf ball—but its location virtually guarantees problems if something goes awry. The prostate gland is located just below the bladder and in front of the rectum. It also wraps around the upper part of the urethra, the tube that carries urine from the bladder out of the body. That means prostate problems can affect urination and sexual function. The prostate is prone to three main conditions: Prostatitis: infection or inflammation of the prostate. Prostatitis can cause burning or painful urination, the urgent need to urinate, trouble urinating, difficult or painful ejaculation, and pain in the area between the scrotum and rectum (known as the perineum) or in the lower back. Benign prostatic hyperplasia: aging-related enlargement of the prostate gl...